Anti-Phospho-IRS1 (Y612) Antibody
Boster Bio Anti-Phospho-IRS1 (Y612) Antibody catalog # P00268-4. Tested in ELISA applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Insulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS-1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1 (IGF-1) receptors to intracellular pathways PI3K/Akt and Erk MAP kinase pathways. IRS1 also plays important biological function for both metabolic and mitogenic (growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.
Synonyms
HIRS 1; IRS 1; IRS1; IRS-1
Gene Name
IRS1
UniProt
P35568
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human IRS1 around the phosphorylation site of Tyr612.
Clonality
Polyclonal
Applications
ELISA
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Applications Notes
ELISA, 1:100-1000
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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