Anti-Phospho-DNA-PKcs/PRKDC (T2647) Antibody
Boster Bio Anti-Phospho-DNA-PKcs/PRKDC (T2647) Antibody catalog # P00645-2. Tested in WB, IHC, ICC, IF applications. This antibody reacts with Human.
Product Specifications
Background
PRKDC (Protein Kinase DNA-Activated Catalytic Subunit), also called DNAPK, HYRC1, p350 or DNPK1, is an enzyme that in humans is encoded by the PRKDC gene. DNA-PKcs belongs to the phosphatidylinositol 3-kinase-related kinase protein family. Satoh et al. (1997) mapped the MCM4 gene to 8q11.2 by FISH. Based on the close proximity of the PRKDC and MCM4 genes, it was assumed that the PRKDC gene also maps to this location. Anderson and Lees-Miller (1992) noted that DNA-PK had been shown in vitro to phosphorylate several transcription factors, suggesting that it functions in cell homeostasis by modulating transcription. Daniel et al. (1999) demonstrated that the PRKDC protein participates in retroviral DNA integration, which is catalyzed by the viral protein integrase.
Synonyms
DNA PK catalytic subunit; DNAPK; DNA-PKcs; DNPK1; HYRC; HYRC1; p350; p460; PRKDC; XRCC7
Gene Name
PRKDC
UniProt
P78527
Host
Rabbit
Reactivity
Human
Immunogen
A synthesized peptide derived from human DNA-PK around the phosphorylation site of Thr2647.
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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