Anti-Phospho-PKM2/PKM (Y105) Antibody
Boster Bio Anti-Phospho-PKM2/PKM (Y105) Antibody catalog # P01173-1. Tested in WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
PKM (Pyruvate Kinase, Muscle), also known as PK3 or PKM2, is an enzyme that in humans is encoded by the PKM gene. The activity of pyruvate kinase subtype M2 is increased by fructose 1, 6-bisphosphate (Fru-1, 6-P2) . By in situ hybridization, Popescu and Cheng (1990) mapped the THBP1 gene to 15q24-q25. Ashizawa et al. (1991) manipulated the intracellular Fru-1, 6-P2 concentration in several mammalian cell lines, including human, by varying the glucose concentration in the media. Using a novel proteomic screen for phosphotyrosine-binding proteins, Christofk et al. (2008) observed that PKM2 binds directly and selectively to tyrosine-phosphorylated peptides.
Synonyms
CTHBP; OIP 3; OIP3; Opa interacting protein 3; p58; PK2; PK3; PKM; PKM2; PK-M2; PKM2 pyruvate kinase; muscle; Pyruvate kinase 2/3; Pyruvate kinase isozymes M1/M2; Pyruvate kinase muscle isozyme; TCB; THBP1; Tumor M2 PK
Gene Name
PKM
UniProt
P14618
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human PKM2 around the phosphorylation site of Tyr105.
Clonality
Polyclonal
Applications
WB, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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