Anti-Phospho-CDK5 (S159) Antibody
Boster Bio Anti-Phospho-CDK5 (S159) Antibody catalog # P00511-1. Tested in WB, IHC, ICC, IF applications. This antibody reacts with Human, Mouse, Rat, Monkey.
Product Specifications
Background
CDK5, Cyclin-Dependent Kinase5, is also known as PSSALRE. The p34 (CDC2) protein kinase regulates important transitions in the eukaryotic cell cycle.The PSSALRE expression is in all human tissues and cell lines tested.The the CDK5 gene is mapped to chromosome 7q36. Cyclin-dependent kinase-5 is predominantly expressed in neurons where it phosphorylates both high molecular weight neurofilaments and microtubule-associated protein tau. CDK5 is required for proper development of the mammalian central nervous system. To be activated, CDK5 must associate with its regulatory subunit, p35 (CDK5R1) . CDK5 can phosphorylate DARPP32 at threonine-75, converting it into an inhibitor of PKA.
Synonyms
CDK5; Cell division protein kinase 5; cyclin dependent kinase 5; PSSALRE; TPKII catalytic subunit
Gene Name
CDK5
UniProt
Q00535
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
A synthesized peptide derived from human CDK5 around the phosphorylation site of Ser159.
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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