Anti-Phospho-SHC/SHC1 (S36) Antibody
Boster Bio Anti-Phospho-SHC/SHC1 (S36) Antibody catalog # P00796. Tested in WB, IHC, ICC, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
SHC, also known as SHC1 (SHC-transforming protein 1) or SHCA, is a protein that in humans is encoded by the SHC1 gene. SCOP classifies the 3D structure as belonging to the SH2 domain family. This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
SH2 domain protein C1; SHC; SHC transforming protein 1; SHC transforming protein 3; SHC transforming protein A; SHC1; SHCA
Gene Name
SHC1
UniProt
P29353
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthesized peptide derived from human SHC around the phosphorylation site of Ser36.
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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