Anti-Phospho-HDAC6 (S22) Antibody
Boster Bio Anti-Phospho-HDAC6 (S22) Antibody catalog # P00595. Tested in WB, IHC, ICC, IF applications. This antibody reacts with Human, Mouse.
Product Specifications
Background
HDAC6, also called KIAA0901, is a member belongs to class II of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC6 gene. The HDAC6 gene is mapped to chromosome Xp11.23. HDAC6 contains an internal duplication of two catalytic domains which appear to function independently of each other. The protein possesses histone deacetylase activity and represses transcription. HDAC6 functions as a tubulin deacetylase. And it is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex. HDAC6 could bind both polyubiquitinated misfolded proteins and dynein motors, thereby recruiting misfolded protein cargo to dynein motors for transport to aggresomes. Furthermore, expression of HDAC6 was sufficient to rescue degeneration associated with UPS dysfunction in vivo in an autophagy-dependent manner. HDAC6 is a central component of the stress response that regulates SG formation and potentially contributes to control of RNA metabolism and translation.
Synonyms
HD6; HDAC6; histone deacetylase 6; JM21; KIAA0901
Gene Name
HDAC6
UniProt
Q9UBN7
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A synthesized peptide derived from human HDAC6 around the phosphorylation site of Ser22.
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
