Anti-Phospho-TAK1/MAP3K7 (T184/T187) Antibody
Boster Bio Anti-Phospho-TAK1/MAP3K7 (T184/T187) Antibody catalog # P01458-1. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Mitogen-activated protein kinase kinase kinase 7, also known as TAK1, is an enzyme that in humans is encoded by the MAP3K7 gene. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Synonyms
MAP3K7; TAK1; TGF1a
Gene Name
MAP3K7
UniProt
O43318
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human TAK1 around the phosphorylation site of Thr184/187.
Clonality
Polyclonal
Applications
WB
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Applications Notes
Western blot, 1:500-2000
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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