Anti-Phospho-SMAD7 (S249) Antibody
Boster Bio Anti-Phospho-SMAD7 (S249) Antibody catalog # P00784. Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3) . Several transcript variants encoding different isoforms have been found for this gene.
Synonyms
CRCS3; hSMAD7; MAD homolog 7; MAD homolog 8; MADH7; MADH8; Mothers against DPP homolog 7; Mothers against DPP homolog 8; SMAD 7; SMAD family member 7; SMAD7
Gene Name
SMAD7
UniProt
O15105
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human Smad7 around the phosphorylation site of Ser249.
Clonality
Polyclonal
Applications
IHC
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Applications Notes
Immunohistochemistry, 1:50-400
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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