Anti-Phospho-PARK2/Parkin/PRKN (S65) Antibody
Boster Bio Anti-Phospho-PARK2/Parkin/PRKN (S65) Antibody catalog # P31800. Tested in WB, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Parkin is a RING domain-containing E3 ubiquitin ligase involved in proteasome-dependent degradation of proteins. It is mapped to 6q26. This gene is important for mitochondrial quality control by lysosome-dependent degradation of damaged mitochondria through autophagy, or mitophagy. Parkin is expressed in neuronal processes and cell bodies of neurons, but not glial cells, in the midbrain, basal ganglia, cerebral cortex, and cerebellum. Parkin assimilated with actin filaments, suggesting that it is a cytoskeletal-associated protein. Parkin is identified as a transcriptional repressor of p53 independent of its ubiquitin ligase function. It also has been found that parkin was associated physically with mitochondrial DNA (mtDNA) in proliferating as well as in differentiated SH-SY5Y neuroblastoma cells.
Synonyms
AR JP; LPRS2; PARK2; PARK2/Parkin; Parkin; Parkinson disease protein 2; PDJ; PRKN
Gene Name
PRKN
UniProt
O60260
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human Parkin around the phosphorylation site of Ser65.
Clonality
Polyclonal
Applications
WB, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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