Anti-Phospho-PERK/EIF2AK3 (T982) Antibody
Boster Bio Anti-Phospho-PERK/EIF2AK3 (T982) Antibody catalog # P01992-1. Tested in WB, IHC, ICC, IF applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
Eukaryotic translation initiation factor 2-alpha kinase 3, also known as protein kinase R (PKR) -like endoplasmic reticulum kinase (PERK), is an enzyme that in humans is encoded by the EIF2AK3 gene. The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Synonyms
EIF2AK3; HRI; HsPEK; Pancreatic eIF2 alpha kinase; PEK; PERK; PERK/EIF2AK3; WRS
Gene Name
EIF2AK3
UniProt
Q9NZJ5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthesized peptide derived from human PERK around the phosphorylation site of Thr982.
Clonality
Polyclonal
Applications
WB, IHC, ICC, IF
Purification
Protein A affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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