Anti-Phospho-AKT1/2/3 (S473) Antibody

Akt, also referred to as PKB or Rac, plays a critical role in controlling survival and apoptosis. This protein kinase is activated by insulin and various growth and survival factors to function in a wortmannin-sensitive pathway involving PI3 kinase. Akt is activated by phospholipid binding and activation loop phosphorylation at Thr308 by PDK1 and by phosphorylation within the carboxy terminus at Ser473. The previously elusive PDK2 responsible for phosphorylation of Akt at Ser473 has been identified as mammalian target of rapamycin (mTOR) in a rapamycin-insensitive complex with rictor and Sin1.

AKT; AKT1; PKB; PKB ALPHA; PRKBA; Protein kinase B; Proto oncogene c Akt; RAC; RAC ALPHA; RAC PK alpha; AKT2; PKB beta; PKBB; PKBBETA; PRKBB; Protein kinase Akt 2; Protein kinase B beta; RAC BETA; RAC PK beta; AKT3; PKB GAMMA; PKBG; PRKBG; Protein kinase Akt 3; Protein kinase B gamma; RAC gamma; RAC PK gamma; STK 2