Human recombinant PD-L1 protein, AF
PD-L1 regulates immune responses by binding to the immunoinhibitory receptor PD-1 on activated T-cells and B-cells. This interaction can suppress T-cell responses by inducing apoptosis and arresting cell-cycle progression. In cancer, PD-L1's role in reducing antigen-specific T cells can promote tumor growth and immune evasion. As a result, PD-L1 is considered as a potential therapeutic target for autoimmune diseases and cancer.
Product Specifications
Synonyms
CD274, B7-H1
Gene Name
CD274
UniProt
Q9NZQ7
Reactivity
Human
Tag
His Tag (C-term)
Source
HEK293 cell
Applications
Cell Culture
Purification
>95% as determined by SDS-PAGE.
Endotoxin
<0.1 EU per 1 μg of the protein by the LAL method.
Bioactivity
Testing in process
Form
Reconstitution
Molecular Weight
The protein has a calculated MW of 26 kDa. The protein migrates as 30-35 kDa uder reducing condition (SDS-PAGE analysis) .
Storage Conditions
AA Sequence
A DNA sequence encoding Human PD-L1 Protein (#Q9NZQ7.1) (Phe19-Arg238) was expressed with polyhistidine tag at the C-terminus.
Frequently Asked Questions
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