Human recombinant CNTF (Ciliary neurotrophic factor) protein, AF
Ciliary neurotrophic factor (CNTF) is the member of IL-6 cytokine family and expressed in the nervous system. CNTF is 22.9 kDa neurotrophic factor containing 200 residues, which shows multiple effects in vertebrate retinogenesis. Besides, CNTF acts as a promoter that not only accelerates adult neurogenesis but also increases the survival of neuron after injury. On the other hands, reducing number of hippocampal GABAergic interneurons, as well as 5-HT levels and 5-HT1A receptor expression has been found in CNTF knockout female mice, indicating that CNTF may influence affective behavior in females by regulation of neurotransmission.
Product Specifications
Synonyms
HCNTF
Gene Name
CNTF
UniProt
P26441
Reactivity
Human
Tag
His Tag (C-term)
Source
Escherichia coli
Applications
Cell Culture
Purification
>98% as determined by SDS-PAGE.
Endotoxin
<0.01 EU per 1 μg of the protein by the LAL method.
Bioactivity
Measure by its ability to induce proliferation in TF-1 cells. The ED50 for this effect is <0.15 μg/mL.
Form
Reconstitution
Molecular Weight
The protein has a calculated MW of 23.74 kDa. The protein migrates as 25 kDa under reducing condition (SDS-PAGE analysis) .
Storage Conditions
AA Sequence
Frequently Asked Questions
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