Anti-HLA-DRB5 Antibody
Boster Bio Anti-HLA-DRB5 Antibody catalog # A01789. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.
Product Specifications
Background
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. There are multiple pseudogenes of this gene.
Synonyms
HLA DRB; Dw2; DR2-beta-2; DR beta-5; DR beta 5
Gene Name
HLA-DRB5
UniProt
Q30154
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E.coli-derived human HLA-DRB5 recombinant protein (Position: C3-G263) .
Clonality
Polyclonal
Applications
WB, IHC
Purification
Immunogen affinity purified.
Concentration
500 μg/mL
Form
Liquid
Storage Conditions
12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.
Gene Name Synonym
Major histocompatibility complex, class II, DR beta 5
Protein Name
HLA class II histocompatibility antigen, DR beta 5 chain
Contents
500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.
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