Human recombinant GFAP protein, AF

GFAP (Glial Fibrillary Acidic Protein) is a protein primarily found in CNS astrocytes. Increased GFAP immunoreactivity indicates gliosis, a response to neural damage. GFAP defects cause Alexander disease, a rare CNS disorder with astrocytic Rosenthal fiber accumulation. The infantile form leads to myelination failure and early mortality, while the juvenile or adult forms present with ataxia, bulbar signs, spasticity, progressing more gradually.