Human recombinant CCL2 (C-C motif chemokine ligand 2) protein, AF
C-C Motif Chemokine Ligand 2 (CCL2) is an 8.44 kDa cytokine with 76 amino acid residues and is also known as monocyte chemoattractant protein 1 (MCP1) . The CCL2 secreted from monocytes, macrophages, and dendritic cells. Upon binding with CCR4, it regulates many biological functions, such as recruitments of monocytes, memory T cells, and dendritic cells, response to TNF-α and Interferon-γ, angiogenesis, cellular homeostasis, and cytoskeleton organization.
Product Specifications
Synonyms
Monocyte Chemotactic Protein-1, MCP-1
Gene Name
CCL2
UniProt
P13500
Reactivity
Human
Tag
His Tag (N-term)
Source
Escherichia coli
Applications
Cell Culture
Purification
>95% as determined by SDS-PAGE.
Endotoxin
<0.1 EU per 1 μg of the protein by the LAL method.
Bioactivity
Measure by its ability to chemoattract BaF3 cells transfected with human CCR2A. The ED50 for this effect is <20 ng/mL.
Form
Reconstitution
Molecular Weight
The protein has a calculated MW of 9.49 kDa. The protein migrates as 11 kDa under reducing condition (SDS-PAGE analysis) .
Storage Conditions
AA Sequence
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT with polyhistidine tag at the N-terminus.
Frequently Asked Questions
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