Human recombinant BMP-2 (Bone morphogenetic protein-2) protein, AF
Bone Morphogenetic Protein-2 (BMP-2) is an extracellular multifunctional signaling cytokine that is also a member of the TGF-β family. BMP-2 can bind with the TGF-β receptor to active SMAD protein signal transduction. Moreover, it engages in the path of signals such as Wnt and Notch. BMP-2 plays an essential role in the growth of hard bones and cartilage and involved in the differentiation of osteoblasts.
Product Specifications
Synonyms
Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Gene Name
BMP2
UniProt
P12643
Reactivity
Human
Tag
His Tag (C-term)
Source
Escherichia coli
Applications
Cell Culture
Purification
>95% as determined by SDS-PAGE.
Endotoxin
<0.1 EU per 1 μg of the protein by the LAL method.
Bioactivity
Measure by its ability to induce alkaline phosphatase production by ATDC5 cells. The ED50 for this effect is <1.0 μg/mL.
Form
Reconstitution
Molecular Weight
The protein has a calculated MW of 13.76 kDa. The protein migrates as 14 kDa under reducing condition (SDS-PAGE analysis) .
Storage Conditions
AA Sequence
Frequently Asked Questions
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