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CU-115

CU-115 is a potent TLR8 antagonist (IC50=1.04 μM), and shows selective for TLR8 over TLR7 (IC50=>50 μM) . CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells[1].

Product Specifications

CAS Number

2471982-20-2

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cu-115.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F

Molecular Formula

C21H11F7INO2

Molecular Weight

569.21

References & Citations

[1]Rosaura Padilla-Salinas, et al. Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8. J Med Chem. 2019 Nov 27;62 (22) :10221-10244.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR7; TLR8

Available Sizes

Frequently Asked Questions

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