Human recombinant CD28 ECD protein, AF
CD28, a well-known costimulatory receptor expressed on T cells, is a type I transmembrane glycoprotein of the Ig superfamily. When the T cells receive the first signal delivered by APCs (antigen-presenting cells), it initiates signaling cascades, which favor T cell survival and proliferation. It has been demonstrated that patients with lung cancer who responded to PD-1 therapy had more CD28+ T cells, suggesting that CD28 may predict treatment response.
Product Specifications
Synonyms
TP44
Gene Name
CD28
UniProt
P10747
Reactivity
Human
Tag
His-SUMO Tag (N-term)
Source
HEK293 cell
Applications
Cell Culture
Purification
>95% as determined by SDS-PAGE.
Endotoxin
<0.1 EU per 1 μg of the protein by the LAL method.
Bioactivity
Testing in process
Form
Reconstitution
Molecular Weight
The protein has a calculated MW of 28.61 kDa. The protein migrates as 48-62 kDa under reducing condition (SDS-PAGE analysis) .
Storage Conditions
AA Sequence
A DNA sequence encoding Human CD28 ECD (# P10747) (Asn19 – Pro152) was expressed with polyhistidine-SUMO tag at the N-terminus.
Frequently Asked Questions
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