Human recombinant CXCL1 (C-X-C motif chemokine 1) protein, AF
C-X-C motif chemokine 1 (CXCL1) also named Growth-regulated oncogene alpha (GROα), which is a chemokine of the intercrine alpha family. CXCL1 is a 7.9 kDa protein containing 73 amino acid residues. CXCL1 is expressed in immune cells such as macrophage and neutrophils. CXCL1 plays an important role with immune responses and cancer progression. CXCL1 activates the cell signal transduction with casepas1 that affect the cell proliferation, differentiation and migration.
Product Specifications
Synonyms
GRO-α: MGSAα, NAP-3, GRO1
Gene Name
CXCL1
UniProt
P09341
Reactivity
Human
Tag
His Tag (N-term)
Source
Escherichia coli
Applications
Cell Culture
Purification
>98% as determined by SDS-PAGE.
Endotoxin
<0.1 EU per 1 μg of the protein by the LAL method.
Bioactivity
Measure by its ability to chemoattract BaF3 cells transfected with human CXCR2. The ED50 for this effect is <3 ng/mL.
Form
Reconstitution
Molecular Weight
The protein has a calculated MW of 8.67 kDa. The protein migrates as 10 kDa under reducing condition (SDS-PAGE analysis) .
Storage Conditions
AA Sequence
ASVATELRCQCLQTLQGIHPKNIQSVNVKSPGPHCAQTEVIATLKNGRKACLNPASPIVKKIIEKMLNSDKSN with polyhistidine tag at the N-terminus.
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