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Anti-VEGFD Antibody

Boster Bio Anti-VEGFD Antibody (Catalog # M32333) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.

Synonyms

Vascular endothelial growth factor D, VEGF-D, c-Fos-induced growth factor, FIGF, FIGF, VEGFD

Gene Name

VEGFD

UniProt

O43915

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides corresponding to N-terminal, central, and C-terminal sequences of human VEGF4.

Clonality

Monoclonal

Clone

Clone: 28AT743.288.48

Tissue Specificity

Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas

Applications

WB

Field of Research

Cancer, Cardiovascular, Signal Transduction, Immunology, Cytokines

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

40444 Da

Applications Notes

WB: 1:4000

Subcellular Location

Secreted.

Isotype

Mouse IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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