Anti-FAM168B Antibody (Center)
Boster Bio Anti-FAM168B Antibody (Center) (Catalog # M13504) . Tested in IHC, Flow Cytometry, WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Modulates neuronal axonal outgrowth by acting as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27 (By similarity) .
Synonyms
Myelin-associated neurite-outgrowth inhibitor, Mani, p20, FAM168B, KIAA0280L, MANI
Gene Name
FAM168B
UniProt
A1KXE4
Host
Rabbit
Reactivity
Human
Immunogen
This FAM168B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 105-139 amino acids from the Central region of human FAM168B.
Clonality
Polyclonal
Tissue Specificity
Expressed in the brain, within neuronal axonal fibers and associated with myelin sheets (at protein level) . Expression tends to be lower in the brain of Alzheimer disease patients compared to healthy individuals (at protein level)
Applications
IHC, Flow Cytometry, WB
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
20324 Da
Subcellular Location
Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:D4AEP3}. Cell membrane {ECO:0000250|UniProtKB:Q80XQ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80XQ8}. Cell projection, axon {ECO:0000250|UniProtKB:Q80XQ8}. Note=Expressed in neuronal cell bodies and axonal fibers. {ECO:0000250|UniProtKB:Q80XQ8}
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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