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Anti-RAB20 Antibody

Boster Bio Anti-RAB20 Antibody (Catalog # M11018) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Synonyms

Ras-related protein Rab-20, RAB20

Gene Name

RAB20

UniProt

Q9NX57

Host

Mouse

Reactivity

Human

Immunogen

This RAB20 antibody is generated from a mouse immunized with recombinant protein from human RAB20.

Clonality

Monoclonal

Clone

Clone: 1694CT210.218.54

Tissue Specificity

Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level) .

Applications

WB, Flow Cytometry

Field of Research

Cancer, Signal Transduction

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

26277 Da

Subcellular Location

Golgi apparatus. Cytoplasmic vesicle, phagosome Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity) . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211) {ECO:0000250|UniProtKB:P35295, ECO:0000269|PubMed:21255211}

Isotype

IgG2a

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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