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Anti-ASGR2 Antibody (N-term)

Boster Bio Anti-ASGR2 Antibody (N-term) (Catalog # M10123) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Synonyms

Asialoglycoprotein receptor 2, ASGP-R 2, ASGPR 2, C-type lectin domain family 4 member H2, Hepatic lectin H2, HL-2, ASGR2, CLEC4H2

Gene Name

ASGR2

UniProt

P07307

Host

Rabbit

Reactivity

Human

Immunogen

This ASGR2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-54 amino acids from the N-terminal region of human ASGR2.

Clonality

Polyclonal

Tissue Specificity

Expressed exclusively in hepatic parenchymal cells.

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N- acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

35092 Da

Applications Notes

WB: 1:1000

Subcellular Location

Membrane; Single-pass type II membrane protein.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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