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Anti-PSMC2 Antibody

Boster Bio Anti-PSMC2 Antibody (Catalog # M09306) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.

Synonyms

26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, Proteasome 26S subunit ATPase 2, Protein MSS1, PSMC2, MSS1

Gene Name

PSMC2

UniProt

P35998

Host

Mouse

Reactivity

Human

Immunogen

This antibody is generated from a mouse immunized with a recombinant protein from human.

Clonality

Monoclonal

Clone

Clone: 1851CT193.4.40

Applications

WB

Field of Research

Cell Biology, Signal Transduction, Viral process, Host-Virus Interaction, Proteasome

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

48634 Da

Applications Notes

WB: 1:2000

Subcellular Location

Cytoplasm. Note=Colocalizes with TRIM5 in cytoplasmic bodies

Prediction Reactivity

Bovine, Monkey, Mouse

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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