Anti-NSFL1C Antibody (Center)

Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP- mediated formation of transitional endoplasmic reticulum (tER) (By similarity) . Inhibits the activity of CTSL (in vitro) .

This NSFL1C antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 214-248 amino acids from the Central region of human NSFL1C.

Nucleus {ECO:0000250|UniProtKB:O35987}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:O35987}. Chromosome {ECO:0000250|UniProtKB:O35987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O35987} Note=Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks Localizes to centrosome during mitotic prophase and metaphase {ECO:0000250|UniProtKB:O35987}