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Anti-RYK Antibody

Boster Bio Anti-RYK Antibody (Catalog # M07225) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Synonyms

Tyrosine-protein kinase RYK, 2.7.10.1, RYK, JTK5A

Gene Name

RYK

UniProt

P34925

Host

Mouse

Reactivity

Human

Immunogen

This RYK antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 260-565 amino acids from human RYK.

Clonality

Monoclonal

Clone

Clone: 1671CT575.42.61

Tissue Specificity

Observed in all the tissues examined.

Applications

WB, Flow Cytometry

Field of Research

Signal Transduction, Stem Cells

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

67815 Da

Subcellular Location

Membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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