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Anti- (Mouse) Mlf1 Antibody (Center)

Boster Bio Anti- (Mouse) Mlf1 Antibody (Center) (Catalog # M06772-1) . Tested in WB application (s) . This antibody reacts with Mouse.

Product Specifications

Background

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Synonyms

Myeloid leukemia factor 1, Hematopoietic lineage switch 7, Myelodysplasia-myeloid leukemia factor 1, Mlf1, Hls7

Gene Name

Mlf1

UniProt

Q9QWV4

Host

Rabbit

Reactivity

Mouse

Immunogen

This Mouse Mlf1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 91-126 amino acids from the Central region of Mouse Mlf1.

Clonality

Polyclonal

Tissue Specificity

Highly expressed in skeletal muscle, heart, testis. Also found in lung, but not in spleen, thymus, bone marrow, liver and kidney.

Applications

WB

Field of Research

Cardiovascular, Cell Biology, Stem Cells

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

30432 Da

Applications Notes

WB: 1:500

Subcellular Location

Cytoplasm. Nucleus. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Note=Shuttles between the cytoplasm and nucleus.

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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