Anti-RAPGEF1 Antibody (Center)
Boster Bio Anti-RAPGEF1 Antibody (Center) (Catalog # M06527) . Tested in WB application (s) . This antibody reacts with Human.
Product Specifications
Background
Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF) -induced sustained activation of Rap1 and neurite outgrowth.
Synonyms
Rap guanine nucleotide exchange factor 1, CRK SH3-binding GNRP, Guanine nucleotide-releasing factor 2, Protein C3G, RAPGEF1, GRF2
Gene Name
RAPGEF1
UniProt
Q13905
Host
Rabbit
Reactivity
Human
Immunogen
This RAPGEF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 536-569 amino acids from the Central region of human RAPGEF1.
Clonality
Polyclonal
Tissue Specificity
Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver
Applications
WB
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
12432078
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
120548 Da
Applications Notes
WB: 1:2000
Subcellular Location
Early endosome.
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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