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Anti-DKK2 Antibody

Boster Bio Anti-DKK2 Antibody (Catalog # M06431) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .

Synonyms

Dickkopf-related protein 2, Dickkopf-2, Dkk-2, hDkk-2, DKK2

Gene Name

DKK2

UniProt

Q9UBU2

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This DKK2 antibody is generated from a mouse immunized with a recombinant protein of human DKK2.

Clonality

Monoclonal

Clone

Clone: 1833CT856.7.20

Tissue Specificity

Expressed in heart, brain, skeletal muscle and lung

Applications

WB

Field of Research

Stem Cells, Anti-Wnt-Pathway (plus Lgr5) Antibodies

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

28447 Da

Applications Notes

WB: 1:2000

Subcellular Location

Secreted.

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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