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Anti-DENR Antibody

Boster Bio Anti-DENR Antibody (Catalog # M06362) . Tested in WB, IHC-P, Flow Cytometry, IF application (s) . This antibody reacts with Human.

Product Specifications

Background

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Synonyms

Density-regulated protein, DRP, Protein DRP1, Smooth muscle cell-associated protein 3, SMAP-3, DENR, DRP1

Gene Name

DENR

UniProt

O43583

Host

Mouse

Reactivity

Human

Immunogen

This DENR antibody is generated from a mouse immunized with a recombinant protein of human DENR.

Clonality

Monoclonal

Clone

Clone: 1542CT106.51.79

Tissue Specificity

Highly expressed in heart and skeletal muscle and moderately expressed in the brain, placenta, liver and pancreas. Weakly expressed in the lung and kidney.

Applications

WB, IHC-P, Flow Cytometry, IF

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

22092 Da

Isotype

IgG2b, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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