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Anti-PURB Antibody (C-term)

Boster Bio Anti-PURB Antibody (C-term) (Catalog # M06224) . Tested in WB application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Has capacity to bind repeated elements in single- stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine- rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity) .

Synonyms

Transcriptional activator protein Pur-beta, Purine-rich element-binding protein B, PURB

Gene Name

PURB

UniProt

Q96QR8

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This PURB antibody is generated from a mouse immunized with a recombiant protein of human PURB.

Clonality

Monoclonal

Clone

Clone: 2117CT1176.48.6

Tissue Specificity

Expressed in myocardium of heart failure patients.

Applications

WB

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

33241 Da

Applications Notes

WB: 1:8000

Subcellular Location

Nucleus.

Prediction Reactivity

Human, Mouse

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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