Anti-IL28RA Antibody (Center)
Boster Bio Anti-IL28RA Antibody (Center) (Catalog # M05986) . Tested in WB application (s) . This antibody reacts with Human.
Product Specifications
Background
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR) -induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Synonyms
Interferon lambda receptor 1, IFN-lambda receptor 1, IFN-lambda-R1, Cytokine receptor class-II member 12, Cytokine receptor family 2 member 12, CRF2-12, Interleukin-28 receptor subunit alpha, IL-28 receptor subunit alpha, IL-28R-alpha, IL-28RA, Likely interleukin or cytokine receptor 2, LICR2, IFNLR1, IL28RA, LICR2
Gene Name
IFNLR1
UniProt
Q8IU57
Host
Rabbit
Reactivity
Human
Immunogen
This IL28RA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 387-420 amino acids from the Central region of human IL28RA.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
WB
Field of Research
Antiviral Signaling
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR) - induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
57653 Da
Applications Notes
WB: 1:2000
Subcellular Location
Membrane; Single-pass type I membrane protein
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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