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Anti- (DANRE) srrt Antibody (C-Term)

Boster Bio Anti- (DANRE) srrt Antibody (C-Term) (Catalog # M05444) . Tested in WB application (s) . This antibody reacts with Human, Zebrafish.

Product Specifications

Background

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) . Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self- renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) .

Synonyms

Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, srrt, ars2

Gene Name

Srrt

UniProt

Q66I22

Host

Rabbit

Reactivity

Human, Zebrafish

Immunogen

This DANRE srrt antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 733-766 amino acids from DANRE srrt.

Clonality

Polyclonal

Applications

WB

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs (By similarity) . Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=M05444

Product MSDS

https://www.bosterbio.com/msds?sku=M05444

Observed Molecular Weight

103274 Da

Applications Notes

WB: 1:2000

Subcellular Location

Nucleus, nucleoplasm. Cytoplasm. Note=Predominantly nuclear. Shuttles between the nucleus and the cytoplasm (By similarity) .

Isotype

Rabbit IgG

Contents

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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