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Anti-GLS2 Antibody

Boster Bio Anti-GLS2 Antibody (Catalog # M05334) . Tested in WB, IHC-P application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Synonyms

Glutaminase liver isoform, mitochondrial, GLS, 3.5.1.2, L-glutaminase, L-glutamine amidohydrolase, GLS2, GA

Gene Name

GLS2

UniProt

Q9UI32

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This GLS2 antibody is generated from a mouse immunized with a recombinant protein of human GLS2.

Clonality

Monoclonal

Clone

Clone: 1758CT879.217.60

Tissue Specificity

Highly expressed in liver. Expressed in brain and pancreas. Not observed in heart, placenta, lung, skeletal muscle and kidney. Expression is significantly reduced in hepatocellular carcinomas.

Applications

WB, IHC-P

Field of Research

Metabolism, Signal Transduction, Mitochondria

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha- ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

66323 Da

Subcellular Location

Mitochondrion.

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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