Anti-Acetyl-Histone H2A.Z (Lys4) H2AFZ Rabbit Monoclonal Antibody, Clone#RM221

This antibody reacts to Histone H2A.Z acetylated at Lysine 4 (K4ac) . No cross-reactivity with non-modified Lysine 4 or other acetylated Lysines in histone H2A

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.