Anti-Hu CD116 Purified CSF2RA Monoclonal Antibody
Boster Bio Anti-Hu CD116 Purified CSF2RA Monoclonal Antibody (Catalog# M04432) . Tested in Flow Cytometry, IP, WB, IHC-F, MC (CyTOF) application (s) . This antibody reacts with Human.
Product Specifications
Background
CD116 (GM-CSF R alpha) is the low affinity receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF) . CD116 heterodimerizes with CD131, the common beta chain subunit shared with IL-3 and IL5- receptors, to form the high affinity GM-CSF receptor. CD116 is expressed by myeloid cells including macrophages, neutrophils, eosinophils, dendritic cells, and their precursors, as well as on endothelial cells. It is being used as a specific marker of myeloid leukemias.
Synonyms
CSF2RA, GMR, CSF2R, SMDP4, GMCSFR
Gene Name
CSF2RA
UniProt
P15509
Host
Mouse
Reactivity
Human
Immunogen
CD116-transfected COS cells. The mouse monoclonal antibody 4H1 recognizes an extracellular epitope of human CD116, the GM-CSF receptor alpha subunit (approx. 80 kDa) expressed e.g. by neutrophils, eosinophils, monocytes and macrophages.
Clonality
Monoclonal
Clone
Clone: 4H1
Applications
Flow Cytometry, IP, WB, IHC-F, CyTOF
Purification
Purified by protein-A affinity chromatography.
Concentration
1 mg/mL
Form
Liquid
Function
Low affinity receptor for granulocyte-macrophage colony- stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Storage Conditions
Store at 2-8°C. Do not freeze.
Observed Molecular Weight
46207 MW
Applications Notes
Flow cytometry: 1-4 μg/mL.
Gene Name Synonym
Colony stimulating factor 2 receptor alpha subunit
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Protein Name
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha
Isotype
Mouse IgG1 kappa
Contents
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
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