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Anti-UCH37 (UCHL5) Antibody

Boster Bio Anti-UCH37 (UCHL5) Antibody (Catalog # M04276) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L5, UCH-L5, Ubiquitin C-terminal hydrolase UCH37, Ubiquitin thioesterase L5, UCHL5, UCH37

Gene Name

UCHL5

UniProt

Q9Y5K5

Host

Mouse

Reactivity

Human

Immunogen

Purified His-tagged UCH37 protein was used to produced this monoclonal antibody.

Clonality

Monoclonal

Clone

Clone: 854CT5.5.6

Applications

WB

Field of Research

Cell Biology, Proteasome

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

37607 Da

Applications Notes

WB: 1:2000-1:4000

Subcellular Location

Cytoplasm. Nucleus. Note=Associates with the proteasome 19S subunit in the cytoplasm. Associates with the INO80 complex in the nucleus

Isotype

IgG1

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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