Mycophenolic acid glucuronide

Mycophenolic acid glucuronide is a metabolite of the immunosuppressant mycophenolic acid (MPA) . Mycophenolic acid glucuronide shows anti-tumor activity and can be used in adenocarcinoma research[1][2][3].

Product Specifications

CAS Number

[31528-44-6]

UNSPSC

12352005

Hazard Statement

H225, H302+H312+H332, H319

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mycophenolic-acid-glucuronide.html

Purity

99.59

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

C/C(CCC(O)=O)=C\CC(C(O[C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)C(O)=O)=C(C2=O)C(CO2)=C3C)=C3OC

Molecular Formula

C23H28O12

Molecular Weight

496.46

Precautions

H225, H302+H312+H332, H319

References & Citations

[1]Ando K, et al. Synthesis of mycophenolic acid beta-D-glucuronide and its antitumor activity. J Antibiot (Tokyo) . 1970 Aug;23 (8) :408-13.|[2]Natascha A Wolff, et al. Mycophenolic acid (MPA) and its glucuronide metabolites interact with transport systems responsible for excretion of organic anions in the basolateral membrane of the human kidney. Nephrol Dial Transplant. 2007 Sep;22 (9) :2497-503.|[3]Gensburger O, et al. Effect of mycophenolate acyl-glucuronide on human recombinant type 2 inosine monophosphate dehydrogenase. Clin Chem. 2009 May;55 (5) :986-93.