Anti-SAFB-1 monoclonal Antibody
Boster Bio Anti-SAFB-1 monoclonal Antibody catalog # M03458. Tested in WB, ICC applications. This antibody reacts with Human.
Product Specifications
Synonyms
Scaffold attachment factor B1; SAF-B; SAF-B1; HSP27 estrogen response element-TATA box-binding protein; HSP27 ERE-TATA-binding protein; SAFB; HAP, HET, SAFB1
Gene Name
SAFB
UniProt
Q15424
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full length Human SAFB-1.
Clonality
Monoclonal
Tissue Specificity
Ubiquitous. Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines.
Applications
WB, ICC
Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Concentration
1 mg/mL
Form
Liquid
Function
Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (By similarity) . Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity) . Can inhibit cell proliferation. .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
102642 MW
Gene Name Synonym
Scaffold attachment factor B1
Subcellular Location
Nucleus
Protein Name
Scaffold attachment factor B1
Contents
Mouse IgG1, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
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