Anti-BAIAP2 Antibody (C-term)
Boster Bio Anti-BAIAP2 Antibody (C-term) (Catalog # M03306) . Tested in WB application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection.
Synonyms
Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Protein BAP2, Fas ligand-associated factor 3, FLAF3, Insulin receptor substrate p53/p58, IRS-58, IRSp53/58, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53, BAIAP2
Gene Name
BAIAP2
UniProt
Q9UQB8
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Purified His-tagged BAIAP2 protein was used to produced this monoclonal antibody.
Clonality
Monoclonal
Clone
Clone: 1037CT15.1.3
Tissue Specificity
Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta
Applications
WB
Field of Research
Neuroscience
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
60868 Da
Applications Notes
WB: 1:1000
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Cytoplasm, cytoskeleton. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles. Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites
Isotype
IgG2b
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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