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Anti-XRN1 Antibody

Boster Bio Anti-XRN1 Antibody (Catalog # M02855) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity) . Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) .

Synonyms

5'-3' exoribonuclease 1, 3.1.13.-, Strand-exchange protein 1 homolog, XRN1, SEP1

Gene Name

XRN1

UniProt

Q8IZH2

Host

Mouse

Reactivity

Human

Immunogen

This XRN1 antibody is generated from a mouse immunized with arecombinant protein between1455-1706 amino acids from human XRN1.

Clonality

Monoclonal

Clone

Clone: 1647CT536.85.48

Tissue Specificity

Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines

Applications

WB

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity) . Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) .

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

194107 Da

Applications Notes

WB: 1:2000

Subcellular Location

Cytoplasm. Note=Discrete foci at the inner surface of the cell membrane

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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