Anti-CHRM2 Antibody
Boster Bio Anti-CHRM2 Antibody (Catalog # M02733) . Tested in IHC-P, WB, IF, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.
Product Specifications
Background
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
Synonyms
Muscarinic acetylcholine receptor M2, CHRM2
Gene Name
CHRM2
UniProt
P08172
Host
Mouse
Reactivity
Human, Mouse
Immunogen
This antibody is generated from a mouse immunized with a recombinant protein.
Clonality
Monoclonal
Clone
Clone: 1424CT461.78.60
Applications
IHC-P, WB, IF, Flow Cytometry
Field of Research
Neuroscience
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3) ; this then triggers calcium ion release into the cytosol.
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
51715 Da
Subcellular Location
Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization {ECO:0000250|UniProtKB:P06199}
Isotype
IgG1, κ
Contents
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
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