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Anti-CHRM2 Antibody

Boster Bio Anti-CHRM2 Antibody (Catalog # M02733) . Tested in IHC-P, WB, IF, Flow Cytometry application (s) . This antibody reacts with Human, Mouse.

Product Specifications

Background

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.

Synonyms

Muscarinic acetylcholine receptor M2, CHRM2

Gene Name

CHRM2

UniProt

P08172

Host

Mouse

Reactivity

Human, Mouse

Immunogen

This antibody is generated from a mouse immunized with a recombinant protein.

Clonality

Monoclonal

Clone

Clone: 1424CT461.78.60

Applications

IHC-P, WB, IF, Flow Cytometry

Field of Research

Neuroscience

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3) ; this then triggers calcium ion release into the cytosol.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

51715 Da

Subcellular Location

Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization {ECO:0000250|UniProtKB:P06199}

Isotype

IgG1, κ

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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