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Anti-Ntrk3 Antibody

Boster Bio Anti-Ntrk3 Antibody (Catalog # M02502-1) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.

Product Specifications

Background

Receptor for neurotrophin-3 (NT-3) . This is a tyrosine- protein kinase receptor. Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1 (By similarity) .

Synonyms

NT-3 growth factor receptor, GP145-TrkC, Trk-C, Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, Ntrk3, TrkC

Gene Name

Ntrk3

UniProt

Q6VNS1

Host

Mouse

Reactivity

Human, Mouse, Rat

Immunogen

This Ntrk3 antibody is generated from a mouse immunized with a recombinant protein of human Ntrk3.

Clonality

Monoclonal

Clone

Clone: 1454CT394.87.35

Tissue Specificity

Isoform 2 expression is restricted to specific areas in adult brain. Isoform 3 transcripts are readily detected early during embryogenesis and are expressed predominantly in adult brain and gonads.

Applications

WB

Field of Research

Cancer, Neuroscience

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

92760 Da

Applications Notes

WB: 1:1000

Subcellular Location

Membrane; Single-pass type I membrane protein

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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