Anti-Cyclophilin D Antibody
Boster Bio Anti-Cyclophilin D Antibody (Catalog # M02424-1) . Tested in WB, Flow Cytometry, IHC-P, IF application (s) . This antibody reacts with Human.
Product Specifications
Background
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA- binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large- cell lymphoma (ALK+ ALCL) cell lines. May be involved in hepatitis C virus (HCV) replication and release.
Synonyms
Peptidyl-prolyl cis-trans isomerase D, PPIase D, 5.2.1.8, 40 kDa peptidyl-prolyl cis-trans isomerase, Cyclophilin-40, CYP-40, Cyclophilin-related protein, Rotamase D, PPID, CYP40, CYPD
Gene Name
PPID
UniProt
Q08752
Host
Rabbit
Reactivity
Human
Immunogen
This Cyclophilin D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 336-370 amino acids from the human region of human Cyclophilin D.
Clonality
Polyclonal
Tissue Specificity
Widely expressed.
Applications
WB, Flow Cytometry, IHC-P, IF
Field of Research
Cardiovascular, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
1135017520676357
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Observed Molecular Weight
40764 Da
Subcellular Location
Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm
Prediction Reactivity
Mouse, Rat
Isotype
Rabbit IgG
Contents
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Curated Selection
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