Anti-Dkk-3 Monoclonal Antibody
Boster Bio Anti-Dkk-3 Monoclonal Antibody catalog # M02248. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Monkey.
Product Specifications
Synonyms
Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3; DKK3; REIC; UNQ258/PRO295
Gene Name
DKK3
UniProt
Q9UBP4
Host
Mouse
Reactivity
Human, Monkey
Immunogen
Purified recombinant fragment of human Dkk-3 expressed in E. Coli.
Clonality
Monoclonal
Clone
Clone: 4G7
Tissue Specificity
Highest expression in heart, brain, and spinal cord.
Applications
WB, Flow Cytometry, ELISA
Purification
Affinity purification
Concentration
1 mg/mL
Form
Liquid
Function
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) . .
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Observed Molecular Weight
38390 MW
Gene Name Synonym
Dickkopf-related protein 3
Subcellular Location
Secreted.
Protein Name
Dickkopf-related protein 3
Isotype
IgG
Contents
Ascitic fluid containing 0.03% sodium azide.
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