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Anti-Dkk-3 Monoclonal Antibody

Boster Bio Anti-Dkk-3 Monoclonal Antibody catalog # M02248. Tested in WB, Flow Cytometry, ELISA applications. This antibody reacts with Human, Monkey.

Product Specifications

Synonyms

Dickkopf-related protein 3; Dickkopf-3; Dkk-3; hDkk-3; DKK3; REIC; UNQ258/PRO295

Gene Name

DKK3

UniProt

Q9UBP4

Host

Mouse

Reactivity

Human, Monkey

Immunogen

Purified recombinant fragment of human Dkk-3 expressed in E. Coli.

Clonality

Monoclonal

Clone

Clone: 4G7

Tissue Specificity

Highest expression in heart, brain, and spinal cord.

Applications

WB, Flow Cytometry, ELISA

Purification

Affinity purification

Concentration

1 mg/mL

Form

Liquid

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity) . .

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Observed Molecular Weight

38390 MW

Gene Name Synonym

Dickkopf-related protein 3

Subcellular Location

Secreted.

Protein Name

Dickkopf-related protein 3

Isotype

IgG

Contents

Ascitic fluid containing 0.03% sodium azide.

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