Anti-CTBP1 Purified Rabbit Monoclonal Antibody

C-terminal binding protein 1 / brefeldin A (BFA) -dependent ADP-ribosylation substrate (CtBP1/BARS) is a highly conserved transcriptional corepressor, that plays a critical role in regulating gene expression patterns throughout development and in oncogenesis. CtBP regulates target gene transcription, in part, via recruitment of histone deacetylases involved in gene silencing and may act to coordinate histone modifications that regulate gene expression.

Bacterially expressed full-length human CtBP1. The polyclonal antibody reacts with CtBP1, a 49 kDa transcriptional corepressor (intracellular antigen), that plays a critical role in regulating gene expression.

Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.