Anti-TPX2 Antibody

Boster Bio Anti-TPX2 Antibody (Catalog # M01610-1) . Tested in WB application (s) . This antibody reacts with Human.

Product Specifications

Background

Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation.

Synonyms

Targeting protein for Xklp2, Differentially expressed in cancerous and non-cancerous lung cells 2, DIL-2, Hepatocellular carcinoma-associated antigen 519, Hepatocellular carcinoma-associated antigen 90, Protein fls353, Restricted expression proliferation-associated protein 100, p100, TPX2, C20orf1, C20orf2, DIL2, HCA519

Gene Name

TPX2

UniProt

Q9ULW0

Host

Mouse

Reactivity

Human

Immunogen

This TPX2 antibody is generated from a mouse immunized with a recombinant protein between 1-531 amino acids from the human TPX2.

Clonality

Monoclonal

Clone

Clone: 1696CT464.66.9

Tissue Specificity

Expressed in lung carcinoma cell lines but not in normal lung tissues

Applications

Field of Research

Cancer, Cell Biology

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

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Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

85653 Da

Applications Notes

WB: 1:2000

Subcellular Location

Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules