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Anti-RAB27A Antibody

Boster Bio Anti-RAB27A Antibody (Catalog # M01608-1) . Tested in WB, Flow Cytometry application (s) . This antibody reacts with Human.

Product Specifications

Background

Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.

Synonyms

Ras-related protein Rab-27A, Rab-27, GTP-binding protein Ram, RAB27A, RAB27

Gene Name

RAB27A

UniProt

P51159

Host

Mouse

Reactivity

Human

Immunogen

This RAB27A antibody is generated from a mouse immunized with a recombinant protein of human RAB27A.

Clonality

Monoclonal

Clone

Clone: 1590CT813.266.26

Tissue Specificity

Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta Detected in melanocytes, and in most tumor cell lines examined Expressed in cytotoxic T-lymphocytes (CTL) and mast cells

Applications

WB, Flow Cytometry

Field of Research

Signal Transduction, Lysosome

Purification

This antibody is purified through a protein G column, followed by dialysis against PBS.

Function

30771381

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Observed Molecular Weight

24868 Da

Subcellular Location

Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065) . Localizes to endosomal exocytic vesicles (PubMed:17237785) .

Isotype

IgG1, k

Contents

Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

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